Dr. Jakob Fuhrmann
Postdoctoral fellow Department of Chemistry; Department of Molecular TherapeuticsThe Scripps Research Institute
The Chemical Biology of Protein Arginine Phosphorylation
Abstract:
Protein phosphorylation is a central mechanism of cellular signaling in both eukaryotic and prokaryotic organisms. The most common and best characterized type of protein phosphorylation is O-phosphorylation, where the phosphoryl group is attached to the side chain hydroxyl group of serine, threonine and tyrosine residues to generate a phosphate monoester. Recently, it was shown that phosphorylation of arginine can also occur. There, the protein kinase McsB was identified to specifically phosphorylate arginine residues, while the protein phosphatase, YwlE, efficiently hydrolyzes the generated phosphoramidate (P-N) bond. In this presentation Dr. Fuhrmann will present the intriguing discovery of the first protein arginine kinase and the subsequent biochemical and structural studies performed on the corresponding protein arginine phosphatase. Moreover, he will highlight the development of novel chemical tools to study the regulation of protein arginine phosphorylation. Based on these results, Dr. Fuhrmann will provide an outlook on the potential physiological role of this novel type of post-translational protein modification.
All are invited to attend!
(After about an hour, students leave, but faculty remain.)
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