Joseph A. Izatt
Michael J. Fitzpatrick Professor of Engineering
Duke University, Durham, North Carolina
Optical technologies such as optical coherence tomography (OCT) which exploit spatial and temporal coherence can obtain micrometer-scale measurements of structure and function inside living biological tissues, while leveraging optical communications technologies to permit real-time imaging in 3D. We have developed implementations of these technologies for multiple applications including super-resolved non-invasive retinal imaging, flexible hand-held interactive clinical diagnostic imaging, and real-time intrasurgical visualization and operative guidance. These advances allow for real time volumetric microstructural imaging in living patients, and extend the benefits of the latest imaging technologies to previously inaccessible patient populations. Using these tools, we have demonstrated live imaging of individual retinal receptor cells both with and without adaptive optics, including the first demonstrations of retinal cone cell imaging in infants and children. We also report on OCT system integration into ophthalmic microsurgery, including surgical microscope-integrated image acquisition, real-time augmented reality visualization, and image-guided tele-operative and cooperative robotic manipulation of surgical tools with micrometer-scale precision.
Joseph A. Izatt is the Michael J. Fitzpatrick Professor of Engineering in the Edmund T. Pratt School of Engineering, Professor of Ophthalmology, and Program Director for Biophotonics at the Fitzpatrick Institute for Photonics at Duke University. Prof. Izatt's research interests include biomedical optics and spectroscopy, coherence-based tomographic optical imaging, and novel instrumentation for intrasurgical visualization and manipulation. Dr. Izatt is a Fellow of the American Institute for Medical and Biological Engineering (AIMBE), Society of Photo-Instrumentation Engineers (SPIE), Optical Society of America (OSA), and National Academy of Inventors (NAI).