Graph-centric approaches for understanding the mutational landscape of life

Thursday, March 8, 2018 11:30 a.m. to 12:30 p.m.

“Graph-centric approaches for understanding the mutational landscape of life”

Genetic diversity is necessary for survival and adaptability of all forms of life. The importance of genetic diversity is observed universally in humans to bacteria. Therefore, it is a central challenge to improve our ability to identify and characterize the extent of genetic variants in order to understand the mutational landscape of life. In this talk, I will focus on two important instances of genetic diversity found in (1) human genomes (particularly the human leukocyte antigens—HLA) and (2) bacterial genomes (rearrangement of insertion sequence [IS] elements).

Speaker: Dr. Heewook Lee
Heewook Lee is currently a Lane Fellow at Computational Biology Department at the School of Computer Science in Carnegie Mellon University, where he works on developing novel assembly algorithms for reconstructing highly diverse immune related genes, including human leukocyte antigens.

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genomics Bioinformatics